1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE Chemical Properties

Melting point:

48-50 °C (lit.)

Boiling point:

277.1±10.0 °C(Predicted)

Density 

2.065±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

color 

White to Orange to Green

InChI

InChI=1S/C5H6Br2Cl2/c6-5(7)1-4(5,2-8)3-9/h1-3H2

InChIKey

RCRVZCIUKQNOIS-UHFFFAOYSA-N

SMILES

C1(Br)(Br)CC1(CCl)CCl

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2902190000

MSDS

• Language:English Provider:SigmaAldrich

1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE Usage And Synthesis

Uses

1,1-Dibromo-2,2-bis(chloromethyl)cyclopropane may be used as a starting material in the synthesis of [1.1.1]-propellane and ((3-ethynylbicyclo[1.1.1]pentan-1-yl)ethynyl)trimethylsilane.

Preparation

1000 ml 1,1-bis(chloromethyl)-2,2-dibromocyclopropane was added  to a vigorously stirred mixture within 10-15 min, which contains bromoform (370 ml, 4.24 mol), 3-chloro-2-chloromethyl-1-propane (250 g, 2.0 mol), 10 g benzyltriethylammonium chloride, 8 ml ethanol and 200 ml methylene chloride . The temperature was maintained between 25°-35° C. After overnight stirring, 500 ml methylene chloride was added and the thick black mixture was allowed to separate into layers. The top aqueous layer was removed and the bottom layer was gently washed with water (500 ml). 500 ml water was then added and well shaken. Separated the organic phase, treated the residual emulsion with solid sodium chloride and filtered through Celite. All aqueous layers were washed with methylene chloride. The organic extracts were combined, dried over magnesium sulfate, and filtered through Celite. Concentration and vacuum distillation gave the mixture of starting material and black-brown residue which was distilled on a Kugel-Rohr giving  semicrystalline fraction containing the product. Crystallization from 400 ml of pentane from a dry ice-acetone bath gave the white wet crystals. The crude product was dissolved in 400 ml of penfane, then 7.5 g silica gel was added.  Filtered and low temperature recrystallized again. Finally, obtain the product (1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE )

General Description

1,1-Dibromo-2,2-bis(chloromethyl)cyclopropane is a halogenated cyclopropane derivative. It has been reported to be synthesized from 3-chloro-2-(chloromethyl)-1-propene. It is formed as an intermediate during the synthesis of [1.1.1]propellane by Szeimies method.

1,1-DIBROMO-2,2-BIS(CHLOROMETHYL)CYCLOPROPANE(98577-44-7)Related Product Information

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