1-Acetylpiperazine Chemical Properties

Melting point:

31-34 °C (lit.)

Boiling point:

127 °C

Density 

1.0754 (rough estimate)

refractive index 

1.4880 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

methanol: soluble1g/10 mL, clear, colorless to faintly greenish-yellow

pka

8.50±0.10(Predicted)

form 

Liquid After Melting

color 

Clear light yellow

Water Solubility 

Soluble in water 210 g/L (20°C).

Sensitive 

Hygroscopic

BRN 

112220

CAS DataBase Reference

13889-98-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38-36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

F 

3-10-34

Hazard Note 

Irritant

HS Code 

29339900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Acetylpiperazine Usage And Synthesis

Chemical Properties

clear light yellow liquid after melting

Uses

1-Acetylpiperazine may be used in the synthesis of series of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives and 2-substituted-N-(naphth-1-ylmethyl)-pyrimidin-4-amines and 2-substituted-N-benzhydrylpyrimidin-4-amines.

Definition

ChEBI: 1-Acetylpiperazine is a member of phytanoyl-CoAs.

General Description

Infrared and Raman spectra of 1-acetylpiperazine have been recorded in the region of 4000-40cm^-1.

Purification Methods

Purify 1-acetylpiperazine by recrystallisation from 40% aqueous EtOH or from EtOH/Et2O. It is an irritant, and is hygroscopic. The hydrochloride has m 191o (from EtOH), and the tosylate salt has m 148-149o (from EtOH/EtOAc, 1:16). The free base, however, cannot be isolated by basifying the tosylate salt and extraction with CH2Cl2. [Jacobi Chem Ber 66 113 1933, Mosher et al. J Am Chem Soc 75 4949 1953, Hall J Am Chem Soc 78 2570 1956, Beilstein 23 IV 1786.]

1-Acetylpiperazine(13889-98-0)Related Product Information

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