ATPA Chemical Properties

Density 

1.263±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

solubility 

DMSO: 10 mg/mL

form 

solid

pka

2.15±0.10(Predicted)

color 

white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

ATPA Usage And Synthesis

Uses

(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.

Definition

ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid.

Biological Activity

A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .

storage

Desiccate at +4°C

ATPA(140158-50-5)Related Product Information

• ATPA
• ( Z )-2-(2-AMINOTHIAZOL-4-YL)-2-PENTENOIC ACID (ATPA)
• ATPA ((RS)-2-AMINO-3-(3-HYDROXY-5-TERT-B,(R,S)-ATPA,ATPA
• (R)-ATPA, >97%
• (RS)-AMPA
• CHEMBRDG-BB 4009738
• (R,S)-2-AMINO-3-[5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL]PROPIONIC ACID
• 2-ISOXAZOL-4-YL-ETHYLAMINE
• ATPA
• (R)-ATPA
• (S)-ATPA