ChemicalBook > Product Catalog > Biochemical Engineering > Nucleoside drugs > Nucleotides and their analogs > 2,6-Dichloropurine
2,6-Dichloropurine
2,6-Dichloropurine Basic information
- Product Name:
- 2,6-Dichloropurine
- Synonyms:
-
- 2,6-DICHLORO-9H-PURINE
- 2,6-DICHLOROPURINE
- 2,6-Dichloropurine.97%
- 2,6-dichloro-1H-purine
- 1H-Purine, 2,6-dichloro-
- Dichloropurine
- Cefepime Intermediate
- 2,6-dichloro-7H-purine
- CAS:
- 5451-40-1
- MF:
- C5H2Cl2N4
- MW:
- 189
- EINECS:
- 226-681-6
- Product Categories:
-
- Building Blocks
- Chemical Synthesis
- Halogenated Heterocycles
- Heterocyclic Building Blocks
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Biochemistry
- Nucleobases and their analogs
- Nucleotides
- Fused Ring Systems
- Building Blocks
- Halogenated Heterocycles
- Heterocyclic Building Blocks
- PurinesHeterocyclic Building Blocks
- FINE Chemical & INTERMEDIATES
- Starting Raw Materials & Intermediates
- Heterocycles
- Pyridines, Pyrimidines, Purines and Pteredines
- Halides
- Purine
- Nucleotides and Nucleosides
- Purines
- Nucleosides, Nucleotides & Related Reagents
- Nucleic acids
- Bases & Related Reagents
- 5451-40-1
- Mol File:
- 5451-40-1.mol
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2,6-Dichloropurine Chemical Properties
- Melting point:
- 185-195 °C (dec.) (lit.)
- Boiling point:
- 310.62°C (rough estimate)
- Density
- 1.7265 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble
- form
- Crystalline Powder
- pka
- 5.22±0.20(Predicted)
- color
- White to yellow
- Water Solubility
- soluble
- BRN
- 9354
- InChIKey
- RMFWVOLULURGJI-UHFFFAOYSA-N
- CAS DataBase Reference
- 5451-40-1(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 22-24/25-37/39-26-36
- RIDADR
- UN2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29349990
MSDS
- Language:English Provider:2,6-Dichloropurine
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
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2,6-Dichloropurine Usage And Synthesis
Chemical Properties
white to light yellow crystal powder
Uses
Suzuki-Miyaura cross-coupling between halopurines and arylboronic acids in water-acetonitrile.1
Uses
2,6-Dichloropurine is used in the synthesis of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents.
Synthesis Reference(s)
Journal of the American Chemical Society, 80, p. 404, 1958 DOI: 10.1021/ja01535a040
Purification Methods
It can be recrystallised from 150 parts of boiling H2O and dried at 100o to constant weight. It is soluble in EtOAc. The HgCl2 salt separates from EtOH solution. UV: max 275nm ( 8.9K) at pH 1; and 280nm ( 8.5K) at pH 11 [Elion & Hitchings J Am Chem Soc 78 3508 1956, Schaeffer & Thomas J Am Chem Soc 80 3738 1958, Beaman & Robins J Appl Chem (London) 12 432 1962, Montgomery J Am Chem Soc 78 1928 1956]. [Beilstein 26 III/IV 1747.]
2,6-Dichloropurine Preparation Products And Raw materials
Preparation Products
2,6-DichloropurineSupplier
LinkChem Co.,Ltd. Gold
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- 021-021-58950110 13124863828
- sales@linkchem.cn
Changzhou Jintan Maosheng Chemical Plant Gold
- Tel
- 13382827140
- maoshengchem@126.com
Suzhou Tianhong Medicine Chemical Technology Co.,Ltd. Gold
- Tel
- 18949937116
- dongye.huaxue@126.com
Nanjing Redwood Fine Chemical Co., Ltd. Gold
- Tel
- 13851620508 13851620508
- shirly@redwood.com.cn
Shanghai Tuolei Chemical Reagents Co., Ltd.
- Tel
- 86-021-50318510
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2,6-Dichloropurine(5451-40-1)Related Product Information
- Allopurinol
- 2',4'-Dichloroacetophenone
- 1,2-Dichloroethane
- Dichloroethane
- Adenine
- 2,6-DICHLOROPURINE-2'-DEOXYRIBOSIDE
- 2,6-Dichloropurine-9--D-riboside,2,6-Dichloropurine-9-b-D-riboside,2,6-DICHLOROPURINE RIBO,2,6-DICHLOROPURINE-9-BETA-D-RIBOSIDE,2,6-DICHLOROPURINE RIBOSIDE
- 2,6-dichloro-9-(1-methylethyl)-9H-purine
- 2,6,8-TRICHLOROPURINE
- 2,6-Dichloro-7-methylpurine
- DRB
- Cefepime
- Purine
- 2,6-dichloro-9-cyclopentyl-9H-purine
- 9-[2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL]-2,6-DICHLOROPURINE
- 2,6-DICHLORO-9-(2-DEOXY-3,5,DI-O-(4-METHYLBENZOYL-BETA-D-ERYTHROPENTOFURANOSYL)-9H-PURINE)
- 2,6-DICHLORO-9-METHYL-9H-PURINE
- 2,6,8-TRICHLORO-7-METHYLPURINE