PGP-4008 Chemical Properties

storage temp. 

−20°C

solubility 

DMSO: 50mM; Ethanol: 5mM

form 

White to off-white powder.

color 

White to off-white

Safety Information

Hazard Codes 

T

Risk Statements 

45-21/22-34-37-52/53

Safety Statements 

22-24/25-61-45-36/37/39-26-53

WGK Germany 

3

HS Code 

3504009000

MSDS

• Language:English Provider:SigmaAldrich

PGP-4008 Usage And Synthesis

Description

PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). It is effective in vitro and, when delivered intraperitoneally, in vivo, inhibiting tumor growth when given with doxorubicin . PGP-4008 also enhances the ability of docetaxel to inhibit growth and drive apoptosis in ovarian cancer cells.

Uses

PGP-4008 is a specific P-glycoprotein (Pgp) inhibitor. PGP-4008 inhibits tumor growth in a murine syngeneic Pgp-mediated multiple agent resistance (MDR) solid tumor model when given in combination with Doxorubicin[1].

References

[1] Brian D Lee, et al. Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11;47(6):1413-22. DOI:10.1021/jm0303204

PGP-4008(365565-02-2)Related Product Information

• 2-Phenylacetamide