3-(4-Hydroxyphenyl)propionic acid Chemical Properties

Melting point:

129-131 °C(lit.)

Boiling point:

254.38°C (rough estimate)

Density 

1.1708 (rough estimate)

refractive index 

1.5286 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

4.74±0.10(Predicted)

form 

Powder or Granules

color 

Off-white to beige

Water Solubility 

slightly soluble

BRN 

2209841

InChIKey

NMHMNPHRMNGLLB-UHFFFAOYSA-N

LogP

1.100 (est)

CAS DataBase Reference

501-97-3(CAS DataBase Reference)

NIST Chemistry Reference

4-Hydroxyphenylpropionic acid(501-97-3)

EPA Substance Registry System

Benzenepropanoic acid, 4-hydroxy- (501-97-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

MW5342000

Hazard Note 

Irritant

HS Code 

29182990

Toxicity

LD50 intravenous in mouse: 1809mg/kg

MSDS

• Language:English Provider:p-Hydroxyphenyl-propionic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-(4-Hydroxyphenyl)propionic acid Usage And Synthesis

Chemical Properties

Pale-Yellow Crystals

Uses

Antioxidant

Uses

3-(4-Hydroxyphenyl)propionic acid is uses as pharmaceutical intermediates,it is also used as a sensitive fluorogenic substrate for oxidases such as horseradish peroxidase.

Definition

ChEBI: A hydroxy monocarboxylic acid consisting of propionic acid having a 4-hydroxyphenyl group at the 3-position.

Purification Methods

3-p-Hydroxyphenylpropionic acid (phloretic acid) [501-97-3] M 166.2, m 129-130o, 131 -1 3 3o, pKEst(1)~4.7, pKEst(2)~10.1. Crystallise phloretic acid from ether or H2O. [Beilstein 10 IV 631.]

3-(4-Hydroxyphenyl)propionic acid(501-97-3)Related Product Information

• 4'-Hydroxypropiophenone
• 4-Hydroxybenzaldehyde
• Propionic acid
• Citric acid
• 4-Hydroxybenzoic acid
• Hyaluronic acid
• Folic acid
• 4-Hydroxy-D-(-)-2-phenylglycine
• 3-Phenylpropionic acid
• Propionic anhydride
• 4-Methoxyphenol
• Methylparaben
• Ethyl 2-(Chlorosulfonyl)acetate
• 3'-Hydroxypropiophenone
• 4-Hydroxybenzyl alcohol
• 3-(4'-HYDROXYPHENYL)-PROPIONIC ACID-OME,3-(4-HYDROXYPHENYL)PROPIONIC ACID METHYL ESTER
• 4-tert-butyl-3-iodobenzoic acid
• 4-Hydroxybenzyl cyanide