N-acetyl aspartyl-glutaMic acid Chemical Properties

Melting point:

171-173 °C

Boiling point:

769.5±60.0 °C(Predicted)

Density 

1.472±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

H₂O: 50 mg/mL

form 

powder

pka

3.04±0.10(Predicted)

color 

white

optical activity

[α]22/D 34.5°, c = 1.1 in H2O(lit.)

Water Solubility 

Soluble to 100 mM in water

Stability:

Hygroscopic

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29241990

MSDS

• Language:English Provider:SigmaAldrich

N-acetyl aspartyl-glutaMic acid Usage And Synthesis

Chemical Properties

White powder

Uses

N-Acetyl-Asp-Glu has been used in N-acetylated α-linked acidic dipeptidase (NAALADase) assay and affinity experiments.

Uses

N-acetyl aspartyl-glutamic acid is a spaglumic acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.

Definition

ChEBI: A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.

General Description

NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. It remains uncertain whether this compound activates NMDA receptors; however, it is clearly demonstrated to act as a selective agonist of mGluR3, both in vitro and in vivo.

Biochem/physiol Actions

Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.

storage

-20°C

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