(S)-(+)-alpha-Methoxyphenylacetic acid Chemical Properties

Melting point:

64-66 °C(lit.)

Boiling point:

164-166°C 18mm

alpha 

160 º (C=1, MEOH)

Density 

1.1708 (rough estimate)

refractive index 

147 ° (C=0.5, EtOH)

Flash point:

164-166°C/18mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Ethanol (Slightly)

form 

Fine Crystalline Powder or Crystals

pka

3.10±0.10(Predicted)

color 

White

optical activity

[α]17/D +150°, c = 1 in ethanol

Water Solubility 

Soluble

BRN 

2361718

CAS DataBase Reference

26164-26-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneacetic acid, «alpha»-methoxy-, (s)-(26164-26-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29189900

MSDS

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(S)-(+)-alpha-Methoxyphenylacetic acid Usage And Synthesis

Chemical Properties

White Solid

Uses

(S)-(+)-α-Methoxyphenylacetic Acid (cas# 26164-26-1) is a compound useful in organic synthesis.

Uses

Reactant involved in the synthesis of biologically active molecules including:

• Acyclonucleoside phosphonates structural analogs of adefovir
• Labeled discodermolide for studying binding to tubulin
• 10-Isocyano-4-cadinene used for antifouling activity

Reactant involved in studies of immunostimulating chromanones gonytolides A-C

Reactant involved in:

• Hydroxylations and epoxidations
• Hydrogenations

Purification Methods

Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.]

(S)-(+)-alpha-Methoxyphenylacetic acid(26164-26-1)Related Product Information

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• Folic acid
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