Ethyl 2-oxocyclopentanecarboxylate Chemical Properties

Boiling point:

102-104 °C/11 mmHg (lit.)

Density 

1.054 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.452(lit.)

Flash point:

172 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

pka

12.02±0.20(Predicted)

color 

Clear colorless to pale yellow

Water Solubility 

insoluble

BRN 

387787

InChIKey

JHZPNBKZPAWCJD-UHFFFAOYSA-N

LogP

0.330 (est)

CAS DataBase Reference

611-10-9(CAS DataBase Reference)

NIST Chemistry Reference

Cyclopentanecarboxylic acid, 2-oxo-, ethyl ester(611-10-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-36/37-26

WGK Germany 

3

F 

10

HazardClass 

IRRITANT

HS Code 

29183000

MSDS

• Language:English Provider:2-(Ethoxycarbonyl)cyclopentanone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Ethyl 2-oxocyclopentanecarboxylate Usage And Synthesis

Chemical Properties

clear colourless to pale yellow liquid

Uses

Pharmaceutical intermediate.

Uses

Ethyl 2-oxocyclopentanecarboxylate was used in stereoselective synthesis of (±)-cis,cis-spiro[4.4]nonane-1,6-diol. It was also used in the synthesis of tanikolide.

Synthesis Reference(s)

Journal of the American Chemical Society, 85, p. 207, 1963 DOI: 10.1021/ja00885a021
The Journal of Organic Chemistry, 55, p. 5037, 1990 DOI: 10.1021/jo00304a014
Tetrahedron Letters, 22, p. 1353, 1981 DOI: 10.1016/S0040-4039(01)90316-8

General Description

Phase-transfer benzylation reaction of ethyl 2-oxocyclopentanecarboxylate with benzyl bromide in microreactor has been investigated. Ethyl 2-oxocyclopentanecarboxylate participates in cobalt (II) Schiff′s base complex catalyzed oxidation of primary and secondary alcohols.

Hazard

Vapors are toxic, as is skin contact.

Ethyl 2-oxocyclopentanecarboxylate(611-10-9)Related Product Information

• 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester
• Cyclopentanecarboxylic acid
• Ethyl propiolate
• Ethyl acrylate
• Cyclopentanone
• ISOXADIFEN-ETHYL
• Trinexapac-ethyl
• Ethyl acetate
• Ethanol
• Triethyl orthoformate
• Urethane
• Ethylparaben
• Ethyl acetoacetate
• Ethyl cyanoacetate
• Ethyl cyanoformate
• Ethyl formate
• Benzocaine
• Cyclopropanecarboxylic acid