2-Chlororesorcinol Chemical Properties

Melting point:

94-99 °C

Boiling point:

244.1±20.0 °C(Predicted)

Density 

1.471±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder

pka

7.98±0.10(Predicted)

Appearance

Light brown to yellow Solid

InChI

1S/C6H5ClO2/c7-6-4(8)2-1-3-5(6)9/h1-3,8-9H

InChIKey

SWZVJOLLQTWFCW-UHFFFAOYSA-N

SMILES

Oc1cccc(O)c1Cl

CAS DataBase Reference

6201-65-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41-52/53

Safety Statements 

26-36/37/39-61

WGK Germany 

3

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

2-Chlororesorcinol Usage And Synthesis

Chemical Properties

2-Chlororesorcinol is a white solid, density: 1.471 g/cm3, boiling point: 244.1oC at 760 mmHg, melting point: 94-99oC.

Uses

2-Chlororesorcinol is a phenolic derivative and can be used as a pharmaceutical intermediate for pharmaceutical synthesis and research.

Synthesis

In a dry round-bottomed flask containing anhydrous aluminum trichloride (2. 6 g, 20 mmol) and resorcinol (1. 1 g, 10 mmol), 30 mL of methylene chloride was added. Dichloromethane, seal the mouth of the flask with a rubber stopper equipped with a nitrogen balloon, and add phosphorous trichloride (0. 72 ml, 10 mmol) through the rubber stopper with a syringe under an ice bath, controlling the addition time to about 90 minutes. minutes. The reaction was carried out in an ice bath with stirring for 5 h. The reaction was traced by TLC, and the unfolding agent (dichloromethane methanol=97 3/v/v/v) was observed under a UV lamp at 254 nm . The reaction was stopped and the solution was spun dry. The reaction was stopped, the solution was spun dry, 15 mL of 2N hydrochloric acid was added under an ice bath, and 200 mL of ethyl acetate was added . The organic layer was dried with anhydrous magnesium sulfate and filtered, then spun-dried to give a light yellow solid, which was extracted by column chromatography with the eluent (dichloromethane:methanol=97:1.), collected, spun-dried, and observed at . 5), collected and spun dry to give 2-chloro-1,3-benzenediol.

2-Chlororesorcinol(6201-65-6)Related Product Information

• Hydroquinone
• 2,2-Bis(hydroxymethyl)propionic acid
• (ethylenedioxy)dimethanol
• Chlorobenzene
• Catechol
• Resorcinol
• tert-Butylhydroquinone
• 1,2,4-Trichlorobenzene
• 4-tert-Butylcatechol
• 2,6-Naphthalenediol
• Chlororesorcinol,4-Chlororesorcinol,98%,4-CHLORORESORCINOL / 1-CHLORO-2,4-DIHYDROXYBENZENE,CHLORORESORCINOL(4-),6-chlororesorcino
• 2,4-Dinitrochlorobenzene
• (+)-Griseofulvin
• 4',5'-DICHLOROFLUORESCEIN
• Cloricromene
• TETRACHLOROHYDROQUINONE
• 4-AMINO-6-CHLORORESORCINOL DIMETHYL ETHER
• flambamycin