2,2-DIFLUOROACETOPHENONE Chemical Properties

Melting point:

48-50°C

Boiling point:

53-54°C/12mm

Density 

1.180±0.06 g/mL

refractive index 

1.4955

Flash point:

53-54°C/12mm

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

liquid

Water Solubility 

Immiscible with water.

CAS DataBase Reference

395-01-7

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2914790090

2,2-DIFLUOROACETOPHENONE Usage And Synthesis

Uses

2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

Synthesis Reference(s)

Tetrahedron, 52, p. 15, 1996 DOI: 10.1016/0040-4020(95)00884-B

2,2-DIFLUOROACETOPHENONE(395-01-7)Related Product Information

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