3-BROMO-4-IODOTOLUENE Chemical Properties

Melting point:

265-267 °C

Boiling point:

133 °C

Density 

2,08 g/cm³

refractive index 

1.65

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

color 

Light yellow to Brown

Specific Gravity

2.08

InChI

InChI=1S/C7H6BrI/c1-5-2-3-7(9)6(8)4-5/h2-4H,1H3

InChIKey

PLAKKSAFIZVHJP-UHFFFAOYSA-N

SMILES

C1(I)=CC=C(C)C=C1Br

CAS DataBase Reference

71838-16-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

29039990

3-BROMO-4-IODOTOLUENE Usage And Synthesis

Uses

3-Bromo-4-iodotoluene, is an intermediate for the synthesis of more complex compounds. It is used for the copper-catalyzed synthesis of 2-Arylbenzoxazoles.

Synthesis

General procedure for the synthesis of 3-bromo-4-iodotoluene from 2-bromo-4-methylaniline: 2-bromo-4-methylaniline (5 g, 29 mmol) was dissolved in acetonitrile (80 mL), and an aqueous hydrochloric acid solution prepared from concentrated hydrochloric acid (15 mL) and water (50 mL) was added. The reaction mixture was cooled to 0 °C and a solution of sodium nitrite (2.4 g, 34.87 mmol) in water (50 mL) was added slowly. After addition, the reaction temperature was kept below 5°C for 30 min. Subsequently, a solution of potassium iodide (7.23 g, 43.59 mmol) in water (50 mL) was added. After addition, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was poured into water (300 mL) and extracted with dichloromethane. The organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give a brown oil, which was purified by distillation to give the light yellow target product 3-bromo-4-iodotoluene.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 39, p. 5248 - 5252
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 25, p. 4744 - 4747
[3] Chemistry - A European Journal, 2016, vol. 22, # 6, p. 1941 - 1943
[4] Justus Liebigs Annalen der Chemie, 1873, vol. 168, p. 153
[5] Justus Liebigs Annalen der Chemie, 1878, vol. 192, p. 202

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