GALLEIN Chemical Properties

Melting point:

>300°C

Boiling point:

389.44°C (rough estimate)

Density 

1.2392 (rough estimate)

refractive index 

1.6120 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Solubility Almost insoluble in water, benzene, chloroform; soluble in ethanol, acetone

Colour Index 

45445

pka

5.99(at 25℃)

form 

powder

color 

Brownish-red

PH Range

Yellow (3.8) to rose-red (6.6);Pink (10.6) to violet (13.0)

λmax

526nm

Merck 

14,4344

Stability:

Hygroscopic

Major Application

Organic light emitting devices (OLED), treatment of cancer cells, diagnosis and treatment of amyloidosis, cancer chemo preventive activity, inhibition of influenza virus, semiconductors, photoresists, lithographic printing plates, method for ozone determination, treatment of wastewater, determination of silver, nail polish, monitoring sterilization, determination of proteins, induce apoptosis in cancer cells, treatement of cancer cells, antiHIV agent, cancer chemopreventive activity, drug design

CAS DataBase Reference

2103-64-2

EPA Substance Registry System

Gallein (2103-64-2)

Safety Information

HS Code 

2918.99.4700

GALLEIN Usage And Synthesis

Chemical Properties

Containing 1.5 molecules of water of crystallization is brownish red crystal or powder. It is greenish yellow without water of crystallization. About 180 ℃ when the loss of water of crystallization, in 180 ℃ above the black, to 300 ℃ does not melt. Soluble in alcohol, acetone and dilute alkali solution, slightly soluble in ether, almost insoluble in water, benzene and chloroform. Appears yellow in strong acidic medium, rose-red in slightly acidic, lavender in neutral medium, purple and then yellow in strong alkaline medium.

Uses

Gallein inhibits neutrophil chemotaxis and inflammation, via the disruption of G protein βγ subunit signaling.

Definition

ChEBI: A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'.

Preparation

3,4,5-Trihydroxybenzoic acid or Benzene-1,2,3-triol?and Phthalic anhydride?in 190 ~ 200 ℃ reaction (namely GALLEIN), and then into sodium salt namely Alizarine Violet.

Biological Activity

Inhibitor of G protein β γ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.

storage

Store at -20°C

Properties and Applications

blue light purple. Free acid soluble in hot water for the big red, soluble in hot ethanol for red light brown. In concentrated sulfuric acid to red light yellow, after dilution with fluorescence red yellow precipitation. Dye aqueous solution to join sodium hydroxide as blue.

GALLEIN(2103-64-2)Related Product Information

• GALLEIN
• Phenolphthalein
• ACID ALIZARIN VIOLET N
• ACID VIOLET 34
• 2,2'-DIHYDROXYDIPHENYL ETHER
• 2,3,4-TRIHYDROXYDIPHENYLMETHANE
• 2-Phenoxyphenol
• 3-ISOPROPYLPHENOL
• 1-(2-METHOXYPHENYL)ETHANOL
• 3-(2-HYDROXY-2-PROPYL)PHENOL
• 3-PHENOXYPHENOL
• 3-ISOPROPYLCATECHOL
• Anthracene
• 2,3,4,4'-TETRAHYDROXYDIPHENYLMETHANE
• 3-hydroxy-2-methoxybenzyl alcohol
• 4-ISOPROPYLCATECHOL
• GALLEIN MONOHYDRATE = PYROGALLOL PHTHALIEN
• GALLEIN MONOHYDRATE