(R)-1-Phenyl-3-propanolamine Chemical Properties

Melting point:

77°C(lit.)

Boiling point:

273.23°C (rough estimate)

Density 

1.0406 (rough estimate)

refractive index 

1.4755 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Dichloromethane (Sparingly), DMSO (Slightly), Methanol (Slightly, Heated)

pka

14.90±0.10(Predicted)

form 

Viscous Liquid or Low Melting Solid

color 

Pale yellow or almost white to slightly yellow

CAS DataBase Reference

170564-98-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

45-36/37/39-26

RIDADR 

UN 3259 8/PG III

HazardClass 

8

PackingGroup 

III

HS Code 

29211990

MSDS

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(R)-1-Phenyl-3-propanolamine Usage And Synthesis

Chemical Properties

pale yellow viscous liquid or almost white

Synthesis

(R)-4-Amino-4-phenyl-1-butene (0.04 mol) was dissolved in 200 ml of methanol in a simple ozonolysis apparatus without gas recycling and was cooled to - 20℃. The ozone generator was fed continuously with air. A concentration of 20 g/m3 (ST. P.) of ozone was produced and was completely reactive in the ozonolysis apparatus. After the end of the ozonolysis, the reaction solution was added dropwise over the course of 10 min to 100 ml of an ice-cooled methanolic sodium borohydride solution (0.9 mol/l). The reaction solution was then warmed to room temperature, and 10 ml of water was added to decompose excess sodium borohydride. After the solvent had been distilled off, the residue was extracted several times with dichloromethane, and the combined organic phases were dried over sodium sulfate and filtered. After the solvent had been distilled off, 0.37 mol of (R)-1-Phenyl-3-propanolamine (melting point 73-74°C) was obtained in 99% enantiomeric excess (93% yield).

(R)-1-Phenyl-3-propanolamine(170564-98-4)Related Product Information

• 3-Amino-3-phenylpropionic acid
• 6-Aminocaproic acid
• Isopropyl alcohol
• 3,4'-DIAMINODIPHENYLMETHANE
• ALTRENOGEST
• Glycine
• 3-Aminopyridine
• 3-Aminophenol
• Acetaminophen
• PHENYL VALERATE
• Diphenyl ether
• Tris(hydroxymethyl)aminomethane
• METHYL (3R)-3-AMINO-3-(4-CHLOROPHENYL)PROPANOATE
• (R)-3-Amino-3-phenyl propionic acid methylester
• (R)-3-Amino-3-phenylpropionicacidethylester
• PHENYL RESIN
• r-Amino Butryric Acid
• 2-Amino-1-phenylpropan-1-ol hydrochloride