4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE Chemical Properties

Melting point:

237-238 °C(Solv: water (7732-18-5))

storage temp. 

Store at RT

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Pale Green

Water Solubility 

Soluble to 100 mM in water

4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE Usage And Synthesis

Uses

p-Chlorophenylguanidine Hydrochloride is an reagent used in the synthesis of pyrimidine derivatives as hSMG-1 inhibitors, potential targets for cancer treatment.

Biological Activity

4-chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].urokinase is a serine protease. its primary physiological substrate is plasminogen, which is an inactive form of plasmin. urokinase plays an important role in vascular diseases and cancer.4-chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with ki value of 6.07 μm and 120 μm, respectively [1].

storage

Store at RT

References

[1]. yang h, henkin j, kim kh, et al. selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. j med chem, 1990, 33(11): 2956-2961.

4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE(14279-91-5)Related Product Information

• Chlorhexidine digluconate
• Chlorhexidine
• Chlorhexidine Diacetate
• Chlorhexidine hydrochloride
• picloxydine
• 4-CHLOROPHENYLGUANIDINE CARBONATE
• PROGUANIL HYDROCHLORIDE
• 1-(4-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE
• Chlorhexidine diacetate
• Cycloguanil
• 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE
• 1,5-BIS-(4-CHLOROPHENYL)-BIGUANIDE HCL
• chlorhexidine phosphanilate
• BUTTPARK 4\01-66
• BUTTPARK 7\02-86
• 1-(3,4-DICHLOROPHENYL)BIGUANIDE HYDROCHLORIDE
• CHLORHEXIDINE-RING-UL-14C DIGLUCONATE
• CHLORHEXIDINE-RING-UL-14C DIHYDROCHLORIDE