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Imidapril

Basic information Safety Supplier Related

Imidapril Basic information

Product Name:
Imidapril
Synonyms:
  • (s)-3-(n-((s)-1-ethoxycarbonyl-3-phenylpropyl)-l-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid
  • IMIDAPRIL
  • (4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic Aci
  • 4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, (4S)-
  • 4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, [4S-[3[R*(R*)],4R*]]-
  • (4S)-3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic Acid Hydrochloride
  • (4S)-3-[(2S)-2-[N-[(1S)-1-(Ethyoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
  • lmidaprfil
CAS:
89371-37-9
MF:
C20H27N3O6
MW:
405.44
Product Categories:
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
89371-37-9.mol
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Imidapril Chemical Properties

Melting point:
195-197°C
alpha 
D20 -71.7° (c = 0.5 in ethanol)
Boiling point:
577.0±60.0 °C(Predicted)
Density 
1.266±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
pka
2.44±0.20(Predicted)
CAS DataBase Reference
89371-37-9(CAS DataBase Reference)
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Imidapril Usage And Synthesis

Description

Imidapril is a new ACE inhibitor launched in Japan as a once-daily therapy for hypertension. Its active metabolite has more potent inhibitory effects on all tissue ACES from spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) than many other ACE inhibitors including enalapril and captopril. It has a very long duration of action. In strokeprone spontaneously hypertensive rats (SHRSP), imidapril is effective in stroke prevention at a considerably lower dose than enalapril. This stroke preventive effect has been suggested to be primarily by an indirect mechanism related to the amelioration of kidney dysfunction.

Chemical Properties

White Solid

Originator

Tanabe (Japan)

Uses

Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive

brand name

Tanatril; Novarok

ImidaprilSupplier

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