Imidapril Chemical Properties

Melting point:

195-197°C

alpha 

D20 -71.7° (c = 0.5 in ethanol)

Boiling point:

577.0±60.0 °C(Predicted)

Density 

1.266±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

form 

Solid

pka

2.44±0.20(Predicted)

color 

White to off-white

CAS DataBase Reference

89371-37-9(CAS DataBase Reference)

Imidapril Usage And Synthesis

Description

Imidapril is a new ACE inhibitor launched in Japan as a once-daily therapy for hypertension. Its active metabolite has more potent inhibitory effects on all tissue ACES from spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) than many other ACE inhibitors including enalapril and captopril. It has a very long duration of action. In strokeprone spontaneously hypertensive rats (SHRSP), imidapril is effective in stroke prevention at a considerably lower dose than enalapril. This stroke preventive effect has been suggested to be primarily by an indirect mechanism related to the amelioration of kidney dysfunction.

Chemical Properties

White Solid

Originator

Tanabe (Japan)

Uses

Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive

Definition

ChEBI: Imidapril is a member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It is a dipeptide, a member of imidazolidines, a dicarboxylic acid monoester, a secondary amino compound, an ethyl ester and a N-acylurea.

brand name

Tanatril; Novarok

Imidapril(89371-37-9)Related Product Information

• Methanol
• Lithium diisopropylamide
• Basic Violet 1
• Methyl acetate
• Acetonitrile
• Methyl acrylate
• Methylparaben
• Kresoxim-methyl
• Paraquat dichloride
• 1,1'-Carbonyldiimidazole
• 1-(2,6-Dimethylphenoxy)-2-propanamine
• Methyl
• Methyl bromide
• Carbonyl iron powder
• NICKEL CARBONYL
• 1-(2-AMINOETHYL)-2-IMIDAZOLIDONE
• Imidapril Diacid
• N-ISOPROPYL-AMINO-ACETIC ACID ETHYL ESTER HCL