E3 ligase Ligand 14 Chemical Properties

Boiling point:

899.5±65.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

pka

9.55±0.10(Predicted)

E3 ligase Ligand 14 Usage And Synthesis

Uses

E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

IC 50

IAP

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168

E3 ligase Ligand 14(2241489-43-8)Related Product Information

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• E3 ligase Ligand-Linker Conjugates 38
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