Thalidomide-NH-CH2-COOH Chemical Properties

Boiling point:

713.9±60.0 °C(Predicted)

Density 

1.637±0.06 g/cm3(Predicted)

solubility 

DMSO : 50 mg/mL (150.93 mM; Need ultrasonic)

pka

3.92±0.10(Predicted)

form 

Solid

InChI

InChI=1S/C15H13N3O6/c19-10-5-4-9(13(22)17-10)18-14(23)7-2-1-3-8(12(7)15(18)24)16-6-11(20)21/h1-3,9,16H,4-6H2,(H,20,21)(H,17,19,22)

InChIKey

LRGLFYOYKPSPJQ-UHFFFAOYSA-N

SMILES

C(O)(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

Thalidomide-NH-CH2-COOH Usage And Synthesis

Definition

Thalidomide-NH-CH2-COOH contains a thalidomide group, an amide, an alkylC2 chain, and a terminal carboxylic acid. This product is ready for conjugation to target proteins for PROTAC R&D. It is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. This compound also can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).