N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Chemical Properties

Boiling point:

513.4±60.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

Soluble to 5 mM in ethanol with gentle warming and to 25 mM in DMSO

form 

Powder

pka

13.18±0.60(Predicted)

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE Usage And Synthesis

Uses

Y-27152, is a prodrug of the Kir6 (KATP) channel opener. It has also shown to produce antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Definition

ChEBI: N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-N-phenylmethoxyacetamide is a 1-benzopyran.

Biological Activity

Prodrug of the K ATP channel opener Y-26763 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide ). Inactive in vitro ; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. In vivo, produces long-lasting antihypertensive effects with minimal tachycardia following oral administration in hypertensive animals.

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE(127408-30-4)Related Product Information

• 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE
• 4-isopropoxybenzonitrile
• 3-CYANOBENZYLAMINE
• Benzenemethanamine, 2-(1-methylethoxy)- (9CI)
• 3-(methylaminomethyl)benzonitrile
• 3-M-TOLYL-DL-BETA-ALANINOL
• N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-(PHENYLMETHOXY)ACETAMIDE
• 4-TERT-BUTOXYBENZONITRILE
• 2-(3-CYANO-PHENYL)ETHANOL
• N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE
• 4-(2-hydroxyethoxy)benzonitrile
• D(-)-AC-ALPHA-PHENYLGLYCINOL
• 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI)
• (S)-1-Phenylethylhydroxylamine
• (S)-3-(1-Aminoethyl)benzonitrile