10H-pyrido(3,2-b)(1,4)benzothiazine Chemical Properties

Melting point:

110.0 to 114.0 °C

Boiling point:

370°C(lit.)

Density 

1.293

storage temp. 

Sealed in dry,Room Temperature

solubility 

Dichloromethane (Slightly), DMSO (Slightly)

pka

4.24±0.20(Predicted)

form 

Solid

color 

Yellow to Dark Yellow

InChI

InChI=1S/C11H8N2S/c1-2-5-9-8(4-1)13-11-10(14-9)6-3-7-12-11/h1-7H,(H,12,13)

InChIKey

UKDZROJJLPDLDO-UHFFFAOYSA-N

SMILES

S1C2=CC=CC=C2NC2=NC=CC=C12

Safety Information

HS Code 

2934.99.4400

10H-pyrido(3,2-b)(1,4)benzothiazine Usage And Synthesis

Uses

10H-Pyrido[3,2-b][1,4]benzothiazine has potential anti-cancer ability as seen through studies.

Synthesis

General procedure for the synthesis of azaphenothiazine from the compound (CAS: 95873-97-5): 15.0 g (119.82 mmol) of intermediate (C) was suspended with 4.36 g (119.82 mmol) of hydrochloric acid in 470 mL of ethanol and the reaction was carried out at reflux for 12 h at 70 °C under nitrogen protection. After completion of the reaction, extraction was carried out with dichloromethane and distilled water and the organic layer was filtered through silica gel. After concentrating the organic solvent, it was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether = 7:3, v/v) to give 20.64 g of intermediate (D) in 86% yield.

References

[1] Patent: KR2015/12906, 2015, A. Location in patent: Paragraph 0197; 0204-0205
[2] Journal of the American Chemical Society, 1958, vol. 80, p. 1651,1653

10H-pyrido(3,2-b)(1,4)benzothiazine(261-96-1)Related Product Information

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• ISOTHIPENDYL
• Oxypendyl
• pipazethate