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tipepidine

Basic information Safety Supplier Related

tipepidine Basic information

Product Name:
tipepidine
Synonyms:
  • 14698-07-8 (Citrate[1:1])
  • 1-Methyl-3-piperidylidenedi(2-thienyl)methane
  • 3-(Di-2-thienylmethylene)-1-methyl-piperidine
  • At 327
  • Bitiodin
  • Brn 0212554
  • Cr/662
  • 3-(Dithien-2-ylmethylene)-1-methylpiperidine
CAS:
5169-78-8
MF:
C15H17NS2
MW:
275.43
Mol File:
5169-78-8.mol
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tipepidine Chemical Properties

Melting point:
64-65°
Boiling point:
bp4-5 178-184°
Density 
1.1947 (rough estimate)
refractive index 
1.5300 (estimate)
pka
8.23±0.20(Predicted)
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Safety Information

Toxicity
LD50 in mice (mg/kg): 294 i.p.; 308 i.m.; 867 orally (Higaki)
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tipepidine Usage And Synthesis

Originator

Sotal,G. Ramon

Definition

ChEBI: Tipepidine is a member of piperidines.

Manufacturing Process

From ethyl 1-methylpiperidine-3-carboxylate (which was prepared by hydrogenation of ethyl nicotinate with Ni-catalyst and then by methylation by action dimethyl sulfate) and 2-thienyl magnesium bromide was synthesized 1,1-di(thiophen-2-yl)-2-(3'-N-methylpiperidine), 3-(di-2-thienylmethylene)-1- methylpiperidine was obtained by dehydration of 1,1-di(thiophen-2-yl)-2-(3'- N-methylpiperidine) by action of base.

Therapeutic Function

Antitussive, Expectorant

tipepidineSupplier

Chengdu Forest Science and Technology Development Co., Ltd.
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