tipepidine Chemical Properties

Melting point:

64-65°

Boiling point:

bp4-5 178-184°

Density 

1.1947 (rough estimate)

refractive index 

1.5300 (estimate)

pka

8.23±0.20(Predicted)

form 

Solid

color 

White to light yellow

Safety Information

Toxicity

LD50 in mice (mg/kg): 294 i.p.; 308 i.m.; 867 orally (Higaki)

tipepidine Usage And Synthesis

Originator

Sotal,G. Ramon

Definition

ChEBI: Tipepidine is a member of piperidines.

Manufacturing Process

From ethyl 1-methylpiperidine-3-carboxylate (which was prepared by hydrogenation of ethyl nicotinate with Ni-catalyst and then by methylation by action dimethyl sulfate) and 2-thienyl magnesium bromide was synthesized 1,1-di(thiophen-2-yl)-2-(3'-N-methylpiperidine), 3-(di-2-thienylmethylene)-1- methylpiperidine was obtained by dehydration of 1,1-di(thiophen-2-yl)-2-(3'- N-methylpiperidine) by action of base.

Therapeutic Function

Antitussive, Expectorant

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