thonzylamine
thonzylamine Basic information
- Product Name:
- thonzylamine
- Synonyms:
-
- thonzylamine
- N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyrimidin-2-yl)ethane-1,2-diamine
- N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
- N,N-Dimethyl-N'-(4-methoxybenzyl)-N'-(2-pyrimidinyl)-1,2-ethanediamine
- N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-(2-pyrimidinyl)-1,2-ethanediamine
- N-[2-(Dimethylamino)ethyl]-N-(4-methoxybenzyl)pyrimidin-2-amine
- NCI-C-60708
- Neohetramine
- CAS:
- 91-85-0
- MF:
- C16H22N4O
- MW:
- 286.37
- EINECS:
- 202-103-8
- Mol File:
- 91-85-0.mol
thonzylamine Chemical Properties
- Boiling point:
- 428.74°C (rough estimate)
- Density
- 1.0426 (rough estimate)
- refractive index
- 1.5850 (estimate)
- storage temp.
- Hygroscopic, Refrigerator, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- pKa 2.17 (Uncertain);8.96 (Uncertain)
- color
- Light Brown to Brown
- Water Solubility
- 5.441g/L(37.5 ºC)
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 91-85-0
- EPA Substance Registry System
- Thonzylamine (91-85-0)
thonzylamine Usage And Synthesis
Uses
Thonzylamine is a selective H1-histamine receptor anatagonists. Tropine esterase inhibitor.
Definition
ChEBI: N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-(2-pyrimidinyl)ethane-1,2-diamine is a member of methoxybenzenes.
General Description
An oily liquid. Used (in the form of the hydrochloride) as an antihistaminic.
Reactivity Profile
thonzylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products.
Synthesis
Thonzylamine is synthesized by treating the sodium salt of 2-(4-methoxybenzyl)aminopyrimidine with N,N-dimethyl-2-chloroethylamine .
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