emylcamate Chemical Properties

Melting point:

56-58.5°

Boiling point:

bp1.0 35°; bp0.7 24°

Density 

0.9441 (estimate)

refractive index 

1.4206 (estimate)

pka

13.54±0.50(Predicted)

CAS DataBase Reference

78-28-4

Safety Information

Toxicity

LD50 oral in mouse: 760mg/kg

emylcamate Usage And Synthesis

Originator

Striatin,MSD,US,1960

Uses

Emylcamate is used in combination with compounds that influence brain function and or psychological state to treat herpes virus infection and outbreaks.

Definition

ChEBI: Emylcamate is a carbamate ester.

Manufacturing Process

30.5 g of 3-methyl-3-pentanol, 8.1 g of potassium cyanate and 16.3 g of trichloroacetic acid are heated while stirring at 45°C to 50°C for 24 hours, neutralized by successive addition of anhydrous sodium carbonate. The precipitate is removed from the reaction mixture. Unreacted 3-methyl-3- pentanol is distilled off and the residue is added to a small volume of distilled water. After precipitation and filtration the resulting 3-methyl-3-pentanol carbamate is dried and recrystallized from petroleum ether. MP 54°C to 55°C.

Therapeutic Function

Tranquilizer

Purification Methods

Crystallise the carbamate from 30% aqueous EtOH. [Beilstein 1 IV 1773.]

emylcamate(78-28-4)Related Product Information

• ETHINAMATE
• fenspiride
• emylcamate
• HEXAPROPYMATE
• Fenspiride hydrochloride
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• 3-ALLYL-4-HYDROXY-4,5-DIMETHYL-5-(4-METHYL-3-PENTENYL)-1,3-OXAZOLIDIN-2-ONE
• SPECS AG-205/37268014
• 1-Pentyn-3-ol,3-ethyl-,carbamate(9CI)
• 4-HYDROXY-4-METHYL-3-(2-PYRIDYLMETHYL)-1-OXA-3-AZASPIRO[4.5]DECAN-2-ONE
• CBI-BB ZERO/001957
• 1-MENTHHYDRAZIDE
• 4,4,6A,6B-TETRAMETHYLHEXAHYDRO-3H-1-OXA-2A,3-DIAZACYCLOPENTA[CD]PENTALEN-2-ONE
• CBI-BB ZERO/001962
• 3-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-HYDROXY-4,5-DIMETHYL-5-(4-METHYL-3-PENTENYL)-1,3-OXAZOLIDIN-2-ONE
• 1-ETHYL-8,9-DIMETHOXY-1,10B-DIMETHYL-1,5,6,10B-TETRAHYDRO[1,3]OXAZOLO[4,3-A]ISOQUINOLIN-3-ONE
• 4,4,6A,6B-TETRAMETHYL-3-PHENYLHEXAHYDRO-3H-1-OXA-2A,3-DIAZACYCLOPENTA[CD]PENTALEN-2-ONE