2-(4-isobutylphenyl)propionaldehyde Chemical Properties

Boiling point:

64-65 °C(Press: 0.2 Torr)

Density 

0.937±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

color 

Colourless

Stability:

Hygroscopic

2-(4-isobutylphenyl)propionaldehyde Usage And Synthesis

Uses

2-(4-Isobutylphenyl)propanal is an impurity of the drug Ibuprofen (I140000), a selective cyclooxygenase inhibitor that also inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.

Production Methods

Numerous methods are known for the synthesis of 2-(4-isobutylphenyl)propionaldehyde. It can be prepared by reaction of p-isobutylacetophenone with methyl chloroacetate using sodium methoxide as catalyst, followed by reaction of the glycidic ester with BF3 to give 2- hydroxy-3-(4-isobutylphenyl)-3-butenoic acid methyl ester, which is subsequently treated with mineral acid Avariant of the process is the hydrolysis of the intermediately formed glycidic ester with alkali to give the corresponding salt of glycidic acid, which is then decarboxylated. In addition, 2-(4-isobutylphenyl)propanal is formed by isomerization of 2-(4-isobutylphenyl)- 2-methyloxirane on Al2O3-SiO2 or anhydrous ZnCl2, by reaction of 1-(4-isobutylphenyl)- 1-chloroethane with dimethylformamide in the presence of Li or Na in tetrahydrofuran, and in good yields by Rh- or Co-catalyzed hydroformylation of p-isobutylstyrene.

2-(4-isobutylphenyl)propionaldehyde(51407-46-6)Related Product Information

• 1-Hydroxyibuprofen
• Ibuprofen Isopropyl Ester
• 1-Oxo Ibuprofen
• Ibuprofen Ethyl Ester
• 1,3-bis(4-isobutylphenyl)butan-1-one
• 2-(4-Methylphenyl)propanoic acid
• Ibuprofen Ester Impurity
• Ibuprofen Impurity 4
• 4'-(2-Methylpropyl)acetophenone
• 4-(2-Methylpropyl)benzeneethanol
• 4-Benzyloxybenzaldehyde
• Ibuprofen EP Impurity I
• 3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID
• Ibuprofen Impurity 2
• CARBOXYIBUPROFEN
• p-Isobutylstyrene
• rac a-Hydroxy Ibuprofen
• Ibuprofen Impurity 10