2-Methoxy-5-fluoro-4-aminopyrimidine Chemical Properties

Melting point:

193 °C

Boiling point:

278.9±43.0 °C(Predicted)

Density 

1.345±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder to crystal

pka

3.63±0.10(Predicted)

color 

White to Almost white

InChI

InChI=1S/C5H6FN3O/c1-10-5-8-2-3(6)4(7)9-5/h2H,1H3,(H2,7,8,9)

InChIKey

BYALTIIVASWNSY-UHFFFAOYSA-N

SMILES

C1(OC)=NC=C(F)C(N)=N1

CAS DataBase Reference

1993-63-1

Safety Information

HS Code 

2933599590

2-Methoxy-5-fluoro-4-aminopyrimidine Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-fluoro-2-methoxy-4-fluoropyrimidinamine using 2-methoxy-4-chloro-5-fluoropyrimidine as starting material: 32.5 g of 2-methoxy-4-chloro-5-fluoropyrimidine (compound of formula III) was added to 170 g of a 10 wt% solution of isopropanol in ammonia, heated to 40-60 °C, and the reaction was stirred for 3-5 hours. After completion of the reaction, it was naturally cooled to room temperature and the solid product was collected by filtration. The solid was washed with isopropanol and dried to give 27.2 g of 5-fluoro-2-methoxy-4-pyrimidinamine (compound of formula II, white solid) in 95.0% molar yield and 99.0% HPLC purity.

References

[1] Patent: CN105272922, 2016, A. Location in patent: Paragraph 0038; 0039; 0040

2-Methoxy-5-fluoro-4-aminopyrimidine (1993-63-1)Related Product Information

• 2,4-Diamino-6-hydroxypyrimidine
• 5-Fluoro-4-hydrazinyl-2-methoxypyrimidine
• 2-Methoxy-5-fluoro-4-aminopyrimidine
• 5-fluoropyrimidin-4-amine
• 5-FLUORO-2-HYDROXYPYRIMIDINE