2,5-Dibromo-3-nitropyridine Chemical Properties

Melting point:

92.0 to 96.0 °C

Boiling point:

272.7±35.0 °C(Predicted)

Density 

2?+-.0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

soluble in Methanol

pka

-5.60±0.20(Predicted)

form 

Solid

color 

Yellow

InChIKey

OQKWPJCAKRVADO-UHFFFAOYSA-N

CAS DataBase Reference

15862-37-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

2,5-Dibromo-3-nitropyridine Usage And Synthesis

Uses

2,5-Dibromo-3-nitropyridine is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Preparation

synthesis of 2,5-Dibromo-3-nitropyridine: To a suspension 5-bromo-3-nitro-pyridin-2-ol (20 g, 91.32 mmol) in toluene (100 ml) was added DMF (0.7 ml, 9.13 mmol) and the mixture was heated to 90??C. (the reaction mixture was protected from light). A solution of POBr3 (31. 41 g, 109.51 mmol) in toluene (40 ml) was added dropwise at 90??C. and the reaction mixture was stirred at that temperature for 16 h. The mixture was allowed to cool to room temperature and toluene (50 ml) and water (50 ml) were added. The organic layer was separated, washed successively with aqueous 1N NaOH (60 ml), water (60 ml) and brine (30 ml), dried with Na2SO4 and evaporated obtain 2,5-Dibromo-3-nitropyridine. Yellow solid, yield 25.2 g, 97%.

2,5-Dibromo-3-nitropyridine(15862-37-0)Related Product Information

• 3,5-Dibromo-4-hydroxybenzaldehyde
• 3,5-Dibromopyridine
• 2,5-Dimethylpyridine
• 2-Chloro-5-chloromethylpyridine
• 3-Aminopyridine
• 2,5-Dibromopyridine
• 3-Nitropyridine
• 2,2-Bis(bromomethyl)propane-1,3-diol
• 1,3-Dibromo-5,5-dimethylhydantoin
• 2,5-Dibromo-3-methylpyridine
• 2,5-DIBROMO-6-METHYLPYRIDINE
• 2,5-Dibromo-4-methylpyridine
• 2-Bromo-3-nitropyridine
• 3,5-DIBROMO-4-NITROPYRIDINE
• 2,6-Dibromo-3-nitropyridine
• 2,3-DIBROMO-5-NITRO PYRIDINE
• 3,5-DIBROMO-2-NITROPYRIDINE
• 2,4-DIBROMO-3-NITROPYRIDINE