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Methyl 4,6-dichloronicotinate

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Methyl 4,6-dichloronicotinate Basic information

Product Name:
Methyl 4,6-dichloronicotinate
Synonyms:
  • Methyl 4,6-dichloronicotinate
  • 4,6-Dichloronicotinic acid methyl ester
  • 100559
  • methyl 4,6-dichloropyridine-3-carboxylate
  • Methyl 4,6-dichloronicotinate 95+%
  • 3-Pyridinecarboxylic acid, 4,6-dichloro-, Methyl ester
  • Methyl 4,6-dichloropyridine-3-carboxylate, 2,4-Dichloro-5-(methoxycarbonyl)pyridine
  • Methyl 4,6-dichloronicotinte
CAS:
65973-52-6
MF:
C7H5Cl2NO2
MW:
206.03
Product Categories:
  • Heterocyclic Compounds
  • Pyridine
  • Esters
  • Pyridines
Mol File:
65973-52-6.mol
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Methyl 4,6-dichloronicotinate Chemical Properties

Melting point:
41-43°
Boiling point:
260.0±35.0 °C(Predicted)
Density 
1.426±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Solid
pka
-1.24±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C7H5Cl2NO2/c1-12-7(11)4-3-10-6(9)2-5(4)8/h2-3H,1H3
InChIKey
JEJMDUMJSZTJTI-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC(Cl)=C1C(OC)=O
CAS DataBase Reference
65973-52-6
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
HazardClass 
IRRITANT
HS Code 
29339900
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Methyl 4,6-dichloronicotinate Usage And Synthesis

Uses

Methyl 4,6-dichloronicotinate could be used to synthesize 4,6-dichloronicotinic acid. Specifically, to a solution of methyl 4,6-dichloronicotinate in a mixture of THF (400 mL), MeOH (100 mL), and H2O (100 mL), a solution of NaOH (10 g) in 40 mL H2O was added. The mixture was stirred for 40 min at room temperature. Then, the solvents were reduced and acidified with concentrated HCl to a pH of about 2. It was extracted using a mixture of Et2O/EtOAc, and the organic layer was dried with Na2SO4. The solvents were removed, and the residue was dried in vacuo to obtain 4,6-dichloronicotinic acid as a white solid (12.3 g, 69% yield).

Methyl 4,6-dichloronicotinate Preparation Products And Raw materials

Preparation Products

Methyl 4,6-dichloronicotinateSupplier

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