3,5-Dibromo-2-methylpyridine Chemical Properties

Boiling point:

227.9±35.0 °C(Predicted)

Density 

1.911±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

1.24±0.20(Predicted)

form 

solid

color 

White to off white

Safety Information

HS Code 

2933399990

3,5-Dibromo-2-methylpyridine Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-methyl-3,5-dibromo-6-methylpyridine from 2-amino-3,5-dibromo-6-methylpyridine: tert-butyl nitrite (1.5 mL, 12.6 mmol) was added to a solution of 2-amino-3,5-dibromo-6-methylpyridine (2.0 g, 7.5 mmol) in tetrahydrofuran (THF, 75 mL). The reaction mixture was heated to reflux and kept for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (SiO2, dichloromethane as eluent) to afford the target product 2-methyl-3,5-dibromopyridine (0.8 g, 42% yield). High performance liquid chromatography (HPLC) analysis showed a retention time (Rt) of 2.77 min.

References

[1] Patent: US2005/192310, 2005, A1. Location in patent: Page/Page column 35

3,5-Dibromo-2-methylpyridine(38749-87-0)Related Product Information

• 3,5-Dibromo-2-methylpyridine
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• 3,5-Dibromo-2-fluoro-6-methylpyridine
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• 3,5-DIBROMO-2-(TRIFLUOROMETHYL)PYRIDINE
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• 3,5-Dibromo-6-methylpyridin-2-ol
• 3,5-DIBROMO-PYRIDIN-2-YL-ALDEHYDE
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