6-Chloropyridazine-3-carboxamide Chemical Properties

Melting point:

232-234 °C(Solv: water (7732-18-5))

Boiling point:

424.6±30.0 °C(Predicted)

Density 

1.478±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

13.62±0.50(Predicted)

color 

Off-white

Safety Information

Hazard Codes 

Xi

HS Code 

2933998090

6-Chloropyridazine-3-carboxamide Usage And Synthesis

Synthesis

1. An excess of gaseous ammonia was slowly passed into a solution of n-butyl 6-chloropyridazine-3-carboxylate (40 g) in methanol (280 ml) in an ice bath. 2. The reaction mixture was stirred at room temperature for 4 h. 3. Upon completion of the reaction, the solid product was collected by filtration and washed with methanol (20 ml). 4. Drying gave 6-chloropyridazine-3-carboxamide (28.05 g, yield 95.5%) with a melting point of 243-245°C. 5. NMR hydrogen spectroscopy (DMSO-d6) data: δ 7.96 (broad peak, 1H), 8.07 (double peak, 1H, J = 8.3 Hz), 8.22 (double peak, 1H, J = 8.3 Hz), 8.52 (broad peak, 1H). 6-Chloropyridazine-3-carboxamide was dried.

References

[1] Patent: US6100258, 2000, A
[2] Patent: US5843942, 1998, A

6-Chloropyridazine-3-carboxamide(66346-83-6)Related Product Information

• N,N-Dimethylformamide
• Sulfachloropyridazine sodium
• Hydralazine
• Chlorantraniliprole
• Thioridazine
• Formamide
• 3,4-Pyridazinediamine, 6-chloro-
• 3-Pyridazinecarboxaldehyde, 6-chloro- (9CI)
• 2-Pyrazinecarboxylic acid, 6-chloro-, ethyl ester
• Pyridazin-3-ylmethanol
• 3-Pyridazineacetic acid
• METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE
• 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid
• 6-Chloropyridazine-3-carboxylic acid
• 6-Chloro-pyridazine-3-carboxylic acid ethyl ester
• 6-Chloropyrazine-2-carboxylic acid
• 3-Pyridazinecarboxylic acid, 6-chloro-,1-methylethyl ester
• 3-Pyridazinesulfonyl chloride, 6-chloro-