Basic information Safety Supplier Related

ALOESIN

Basic information Safety Supplier Related

ALOESIN Basic information

Product Name:
ALOESIN
Synonyms:
  • ALOESIN
  • 4H-1-Benzopyran-4-one, 8-.beta.-D-glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-
  • 2-(2-Oxopropyl)-5-methyl-7-hydroxy-8-(β-D-glucopyranosyl)-4H-1-benzopyran-4-one
  • 8-β-D-Glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
  • Aloe resin B
  • Aloeresin B
  • Aloeresin
  • 4H-1-Benzopyran-4-one, 8-β-D-glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-
CAS:
30861-27-9
MF:
C19H22O9
MW:
394.37
Product Categories:
  • Carbohydrates & Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:
30861-27-9.mol
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ALOESIN Chemical Properties

Boiling point:
628.0±55.0 °C(Predicted)
Density 
1.500±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO:122.67(Max Conc. mg/mL);311.05(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);50.71(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);25.36(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);12.68(Max Conc. mM)
pka
6.58±0.40(Predicted)
form 
Pale yellow to brown powder.
color 
White to off-white
LogP
0.640 (est)
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ALOESIN Usage And Synthesis

Chemical Properties

White needle-shaped crystals, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

Aloeresin is an aromatic chromone present in various Aloe Species has shown potential beneficial effects on indexes related to pre-diabetic states including metabolic syndrome.

Definition

ChEBI: Aloesin is a member of chromones.

in vivo

Aloesin (injection; 20?mg/kg or 40?mg/kg; once daily; 7 w) inhibits tumor growth in a Xenograft model of ovarian cancer[1].

Animal Model:6-week-old athymic nude mice injected with SKOV3 cells
Dosage:20?mg/kg or 40?mg/kg
Administration:Injection; 20?mg/kg or 40?mg/kg; once daily; 7 weeks
Result:Reduced volumes and average weights of dissected tumors significantly compared with the control group.

ALOESINSupplier

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