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YUNACONITINE

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YUNACONITINE Basic information

Product Name:
YUNACONITINE
Synonyms:
  • 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine
  • Yunnaconitine
  • Yunaconitine GuayewuanineB
  • Aconitane-3,8,13,14-tetrol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-(4-methoxybenzoate), (1α,3α,6α,14α,16β)-
  • YUNACONITINE USP/EP/BP
  • Aconitane-3,8,13,14-tetrol,20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate14-(4-methoxybenzoate), (1a,3a,6a,14a,16b)-
  • (3R,4R,6S,6aS,7R,7aR,8R,9S,10S,11aR,12R,12aR,13R,14S)-11a-acetoxy-1-ethyl-4,9-dihydroxy-6,10,13-trimethoxy-3-(methoxymethyl)tetradecahydro-1H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-8-yl 4-methoxybenzoate
  • (1alpha,3alpha,6alpha,14alpha,16beta)-8-(acetyloxy)-20-ethyl...
CAS:
70578-24-4
MF:
C35H49NO11
MW:
659.77
Product Categories:
  • Miscellaneous Natural Products
  • Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
70578-24-4.mol
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YUNACONITINE Chemical Properties

Melting point:
142-144℃
Boiling point:
722.8±60.0 °C(Predicted)
Density 
1.34
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
form 
A solid
pka
12.67±0.70(Predicted)
Stability:
Hygroscopic
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YUNACONITINE Usage And Synthesis

Uses

Yunnaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformat ional changes. Yunnaconitine is a deiterpene alkaloid, known to exhibit cytotoxic activity in human leukemic cell.

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