Mubritinib Chemical Properties

Melting point:

158.0 to 162.0 °C

Boiling point:

620.9±65.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

DMSO : 50 mg/mL (106.73 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

pka

1.45±0.10(Predicted)

form 

powder to crystal

color 

White to Gray to Brown

Safety Information

HS Code 

2934.99.4400

Mubritinib Usage And Synthesis

Uses

Treatment of cancer.

Uses

Mubritinib is used in selective targeting of CTNNB1-, KRAS-or MYC-driven human cancer cell growth by combinations of existing drugs

Biological Activity

Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC 50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC 50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo .

storage

Store at +4°C

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