6-FLUORO-3,4-PYRIDINEDIAMINE Chemical Properties

Boiling point:

303.9±37.0 °C(Predicted)

Density 

1.390±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

4.50±0.49(Predicted)

form 

solid

color 

Faint brown to light brown

Safety Information

HS Code 

2933399990

6-FLUORO-3,4-PYRIDINEDIAMINE Usage And Synthesis

Synthesis

Example 2.5 Synthesis of 2,3-diamino-5-fluoropyridine: 2-amino-5-fluoro-3-nitropyridine (0.42 g, 2.3 mmol) and iron powder (1.6 g, 28 mmol) were dissolved in ethanol (10 mL), followed by addition of water (0.5 mL, 28 mmol) and hydrochloric acid (27 μL, 0.32 mmol). The reaction mixture was heated and refluxed for 1 hour. After that, iron powder (0.2 g, 3.6 mmol) was added additionally and reflux was continued for 30 min. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give 0.3 g of crude product (100% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 3.55 (broad peak, 2H), 4.1 (broad peak, 2H), 6.7 (double peak, 1H), 7.5 (single peak, 1H).

References

[1] Patent: US6265415, 2001, B1

6-FLUORO-3,4-PYRIDINEDIAMINE(212268-13-8)Related Product Information

• 2,3-Diamino-5-methylpyridine
• 2,3-diaMino-5-chloropyrazine
• 2-amino-5-iodo-3-pyridinylamine
• 5-BROMO-4-METHYL-PYRIDINE-2,3-DIAMINE
• 2,3-Diamino-5-trifluoromethylpyridine
• 3,5,6-Trichloropyrid
• 6-FLUORO-3,4-PYRIDINEDIAMINE
• 5-Amino-2-fluoropyridine