5-Bromo-2,3-difluoroanisole Chemical Properties

Melting point:

33-35°C

Boiling point:

193.7±35.0 °C(Predicted)

Density 

1.615±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

color 

Off white

CAS DataBase Reference

261762-35-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

HazardClass 

IRRITANT

HS Code 

2909309090

MSDS

• Language:English Provider:ALFA

5-Bromo-2,3-difluoroanisole Usage And Synthesis

Chemical Properties

White crystalline powder

Synthesis

In a 3000 L reactor, 201.6 kg of potassium hydroxide (KOH), 253.2 kg of 3,4,5-trifluorobromobenzene and 1500 L of methanol were added sequentially. The reaction kettle was sealed, stirring was turned on and heated to 60°C, and the reaction was maintained for 6 hours until the raw materials were basically reacted completely. The reaction mixture was transferred to a crystallization tank, protected by the passage of nitrogen, cooled to -5 °C with stirring and maintained at this temperature for 5 hours to promote crystallization. Subsequent filtration was performed to afford the target product 2,3-difluoro-5-bromoanisole in 92.0% yield and 99.2% purity. The methanol in the filtrate was recycled and processed for use in subsequent reactions.

References

[1] Patent: CN106478377, 2017, A. Location in patent: Paragraph 0037; 0038; 0053; 0054; 0055; 0056; 0061; 0062

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