Eprazinone Chemical Properties

Boiling point:

508.13°C (rough estimate)

Density 

1.0909 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Sealed in dry,Room Temperature

pka

6.83±0.10(Predicted)

CAS DataBase Reference

10402-90-1(CAS DataBase Reference)

Eprazinone Usage And Synthesis

Application

Epradone is mainly used clinically for coughs caused by acute and chronic bronchitis, pneumonia, asthma, and tuberculosis.

Originator

Mucitux,Riom,France,1969

Definition

ChEBI: A member of the class of piperazines in which the two amino hydrogens of piperazine are replaced by 2-benzoylpropyl and 2-ethoxy-2-phenylethyl groups.

Manufacturing Process

61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g (0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and 0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The product is allowed to crystallize, then filtered and washed with alcohol. It is dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water. Yield: 66%. Melting point: 160°C.

Therapeutic Function

Antitussive

Eprazinone(10402-90-1)Related Product Information

• Cefoperazone sodium
• Benproperine phosphate
• Benzoyl peroxide
• BENZOYL ISOCYANATE
• Ethoxyethyne
• Cefoperazone
• Ipriflavone
• Ethoxyquin
• Ethoxyamine hydrochloride
• Cefoperazone sodium +sulbactam sodium(1:1/2:1)
• Pyruvic acid
• Calcium pyruvate
• Acetylacetone
• Ethoxymethylenemalononitrile
• PHENYL VALERATE
• Phenyl salicylate
• BENPROPERINE
• Benzoyl chloride