ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Metabolism > Hydroxylase Inhibitors > Mildronate dihydrate
Mildronate dihydrate
Mildronate dihydrate Basic information
- Product Name:
- Mildronate dihydrate
- Synonyms:
-
- 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate
- Mildronate dihydrate
- Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt
- Meldonium
- Mildronate dihydrate, >=99%
- Mildronate (hydrate)
- 3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate dihydrate
- Meldonium dihydrate
- CAS:
- 86426-17-7
- MF:
- C6H14N2O2.2H2O
- MW:
- 182.218
- EINECS:
- 695-494-3
- Product Categories:
-
- Cardiovascular APIs
- Inhibitors
- 86426-17-7
- Mol File:
- 86426-17-7.mol
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Mildronate dihydrate Chemical Properties
- Melting point:
- 85 - 87°C
- storage temp.
- 2-8°C
- solubility
- H2O: >40mg/mL
- form
- powder
- color
- white to off-white
- Stability:
- Hygroscopic
- InChIKey
- JFWLFLLRLZSBRA-UHFFFAOYSA-N
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Mildronate dihydrate Usage And Synthesis
Appearance
white to off-white powder
Description
Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively.
Uses
Meldonium dihydrate has been used as an anti-ischemic agent to evaluate its protective effects on Ischemia-reperfusion (I/R) in chick embryos.
Biochem/physiol Actions
Meldonium is an Inhibitor of γ-butyrobetaine hydroxylase (BBOX) a key enzyme in the synthesis of carnitine.
Mildronate dihydrateSupplier
CHENGHUI PHARMACEUTICAL GROUP LTD Gold
- Tel
- 0531-58897070 15254140813
- market@jnchsd.com
Jinan Chenghui Shuangda biological Co., LTD
- Tel
- 0531-58897003 15550412551
- market@jnchsd.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
S.Z. PhyStandard Bio-Tech. Co., Ltd.
- Tel
- 0755-4000505016 13380397412
- 3001272453@qq.com
Beijing HuaMeiHuLiBiological Chemical
- Tel
- 010-56205725
- waley188@sohu.com
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