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Mildronate dihydrate

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Mildronate dihydrate Basic information

Product Name:
Mildronate dihydrate
Synonyms:
  • 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate
  • Mildronate dihydrate
  • Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt
  • Meldonium
  • Mildronate dihydrate, >=99%
  • Mildronate (hydrate)
  • 3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate dihydrate
  • Meldonium dihydrate
CAS:
86426-17-7
MF:
C6H14N2O2.2H2O
MW:
182.218
EINECS:
695-494-3
Product Categories:
  • Cardiovascular APIs
  • Inhibitors
  • 86426-17-7
Mol File:
86426-17-7.mol
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Mildronate dihydrate Chemical Properties

Melting point:
85 - 87°C
storage temp. 
2-8°C
solubility 
H2O: >40mg/mL
form 
powder
color 
white to off-white
Stability:
Hygroscopic
InChIKey
JFWLFLLRLZSBRA-UHFFFAOYSA-N
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Mildronate dihydrate Usage And Synthesis

Appearance

white to off-white powder

Description

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively.

Uses

Meldonium dihydrate has been used as an anti-ischemic agent to evaluate its protective effects on Ischemia-reperfusion (I/R) in chick embryos.

Biochem/physiol Actions

Meldonium is an Inhibitor of γ-butyrobetaine hydroxylase (BBOX) a key enzyme in the synthesis of carnitine.

Mildronate dihydrateSupplier

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010-56205725
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