(R)-(-)-alpha-Methoxyphenylacetic acid Chemical Properties

Melting point:

66-68 °C(lit.)

alpha 

-160.4 º (C=1, MEOH)

Boiling point:

164-166°C 18mm

Density 

1.1708 (rough estimate)

refractive index 

-147 ° (C=0.5, EtOH)

Flash point:

164-166°C/18mm

storage temp. 

2-8°C

solubility 

Chloroform, Ethanol, Methanol

pka

3.10±0.10(Predicted)

form 

Fine Crystalline Powder or Needles

color 

White

optical activity

[α]20/D -150±3°, c = 0.5% in ethanol

BRN 

3589257

CAS DataBase Reference

3966-32-3(CAS DataBase Reference)

NIST Chemistry Reference

(R)-(-)-«alpha»-methoxyphenylacetic acid(3966-32-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29189900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

(R)-(-)-alpha-Methoxyphenylacetic acid Usage And Synthesis

Chemical Properties

white fine crystalline powder or needles

Uses

(R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.

General Description

(R)-(?)-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers.

Purification Methods

Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.]

(R)-(-)-alpha-Methoxyphenylacetic acid(3966-32-3)Related Product Information

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