Fmoc-Glycinol Chemical Properties

Melting point:

144-147 °C (lit.)

Boiling point:

502.7±33.0 °C(Predicted)

Density 

1.238±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO, Methanol

form 

Solid

pka

11.38±0.46(Predicted)

color 

White

CAS DataBase Reference

105496-31-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29242990

MSDS

• Language:English Provider:SigmaAldrich

Fmoc-Glycinol Usage And Synthesis

Uses

Fmoc-Glycinol is an Fmoc protected amino alcohol. Fmoc-Glycinol is used in the preparation of amphiphilic lactosides.

reaction suitability

reagent type: cross-linking reagent

Synthesis

GENERAL STEPS: A tetrahydrofuran (600 mL) solution of 2-aminoethanol (30 g, 491 mmol) was added to a 2000 mL round bottom flask, followed by 9-fluorenylmethyl-N-succinimidyl carbonate (166 g, 491 mmol) and triethylamine (199 g, 1.97 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether mixed solvent) to afford 2-(N-fluorenylmethoxycarbonylamino)ethanol (130 g, 93% yield) as a white solid.

References

[1] Journal of the American Chemical Society, 2014, vol. 136, # 47, p. 16683 - 16688
[2] Tetrahedron Letters, 2008, vol. 49, # 41, p. 5890 - 5893
[3] Patent: WO2015/51045, 2015, A2. Location in patent: Page/Page column 160
[4] Patent: US2016/215288, 2016, A1. Location in patent: Paragraph 0602; 0607
[5] Tetrahedron, 2007, vol. 63, # 28, p. 6577 - 6586

Fmoc-Glycinol(105496-31-9)Related Product Information

• FMOC-O-tert-Butyl-L-serine
• Fmoc-Gly-OH
• Fmoc-Asp(OtBu)-OH
• FMOC-GLN-OH
• FMOC-Ala-OH
• Fmoc-Tyr(tBu)-OH
• Fmoc-Leu-OH
• Nalpha-FMOC-L-Asparagine
• FMOC-NLE-OH
• FMOC-PHE-OH
• FMOC-ASP(OTBU)-OPFP
• FMOC-L-Methionine
• FMOC-GLU(OTBU)-OH H2O
• Fmoc-Cys(tBu)-OH
• Nalpha-FMOC-L-Tryptophan
• Fmoc-Lys(Boc)-OH
• FMOC-L-Valine
• Fmoc-Ile-OH