3-Acetyl-2(3H)-oxazolone Chemical Properties

Melting point:

36-38 °C

Boiling point:

100-104 °C(Press: 16 Torr)

Density 

1.383±0.06 g/cm3(Predicted)

pka

-3.04±0.20(Predicted)

3-Acetyl-2(3H)-oxazolone Usage And Synthesis

Uses

3-Acetyloxazolin-2-one is a reagent used to synthesize (+)-(4R,5S)-5-methoxy-4-(phenylmethoxy)-2-oxazolidinone, (-)-(4S,5R)-5-methoxy-4-(phenylmethoxy)-2-oxazolidinone (I), (+)-(4R,5S)-4,5-dimethoxy-2-oxazolidinone and (-)-(4S,5R)-4,5-dimethoxy-2-oxazolidinone.

Synthesis

The general procedure for the synthesis of 3-acetyloxazolidin-2-one from the compound (CAS:60759-48-0) is as follows: 6.80 g of 3-acetyl-5-chloro-oxazolidin-2-one was placed in a Kugelrohr distillation apparatus and distilled under reduced pressure conditions (50 mbar) and a temperature of 180°C. The product (3.80 g) was obtained from a Kugelrohr distillation apparatus. The final product 3-acetyloxazolidin-2-one (3.80 g) was obtained with a molecular weight of 127.1 g/mol (C5H5NO3).

References

[1] Patent: US2013/345128, 2013, A1. Location in patent: Paragraph 0405; 0406

3-Acetyl-2(3H)-oxazolone(60759-49-1)Related Product Information

• Vinyl Carbamate
• Oxazoline
• 3-Acetyl-2(3H)-oxazolone