2-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

InChI

InChI=1S/C8H6N2O2/c1-12-8(11)6-3-2-4-10-7(6)5-9/h2-4H,1H3

InChIKey

ANPYBZGPGODWJD-UHFFFAOYSA-N

SMILES

C1(C#N)=NC=CC=C1C(OC)=O

Safety Information

HS Code 

2933399990

2-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER Usage And Synthesis

Synthesis

2-Carbamoyl nicotinic acid (7.47 g, 45 mmol) was suspended in CH2Cl2 (50 mL) at 0°C and Et3N (13.08 mL, 94 mmol) and methyl chloroformate (7.65 mL, 99 mmol) were added sequentially under stirring. The reaction mixture was stirred at room temperature for 8 h. The reaction mixture was then diluted with CHCl3 (50 mL), washed sequentially with water, dried over MgSO4 and subsequently concentrated in vacuum. The product was washed with hexane and dried to give methyl 2-cyanopyridine-3-carboxylate.

References

[1] Synthesis (Germany), 2015, vol. 47, # 15, p. 2285 - 2293

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