2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Chemical Properties

Melting point:

240 °C

Boiling point:

465.6±45.0 °C(Predicted)

Density 

1.559±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO: 125 mg/mL (609.25 mM)

pka

0.81±0.10(Predicted)

form 

Yellow solid.

color 

Light yellow to yellow

2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Usage And Synthesis

Uses

Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].

References

[1] Volberg T, et al. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J. 1992 May;11(5):1733-42. DOI:10.1002/j.1460-2075.1992.tb05225.x
[2] Wessely O, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997 May;8(5):481-93. PMID:9149900
[3] Banerjee S, et al. Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. Mol Cancer Res. 2005 Mar;3(3):151-62. DOI:10.1158/1541-7786.MCR-04-0130

2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)(122520-79-0)Related Product Information

• AG 99
• TYRPHOSTIN AG 126
• TYRPHOSTIN AG 835
• AG 18
• 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol
• AG 213
• TYRPHOSTIN A51
• AG 1295
• AG 1478