Basic information Safety Supplier Related

Dibenzepin

Basic information Safety Supplier Related

Dibenzepin Basic information

Product Name:
Dibenzepin
Synonyms:
  • 10-[2-(Dimethylamino)ethyl]-5,10-dihydro-5-methyl-11H-dibenzo[b,e][1,4]diazepin-11-one
  • 5-Methyl-10-dimethylaminoethyl-10,11-dihydro-11-oxodibenzo[b,e][1,4]diazepine
  • HF 1927
  • Dibenzepin
  • 10,11-Dihydro-10-[2-(dimethylamino)ethyl]-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11-one
  • 10,11-Dihydro-5-methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepin-11-one
  • 5-Methyl-10-[2-(dimethylamino)ethyl]-5H-dibenzo[b,e][1,4]diazepine-11(10H)-one
  • 4498-32-12
CAS:
4498-32-2
MF:
C18H21N3O
MW:
295.38
Product Categories:
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
4498-32-2.mol
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Dibenzepin Chemical Properties

Melting point:
116-117°C
Boiling point:
bp0.01 185°
Density 
1.1190 (rough estimate)
refractive index 
1.5855 (estimate)
storage temp. 
Refrigerator
solubility 
Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
pka
8.25(at 25℃)
form 
Solid
color 
Light Beige to Brown
CAS DataBase Reference
4498-32-2
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Safety Information

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
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Dibenzepin Usage And Synthesis

Chemical Properties

Crystalline Solid

Originator

Noveril ,Wander,Switz.,1965

Uses

Antidepressant

Definition

ChEBI: 5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone is a dibenzodiazepine.

Manufacturing Process

4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane. After adding a concentrated benzenic solution of β-dimethylamino-ethyl chloride freshly prepared from 3.75 grams of the hydrochloride with concentrated sodium hydroxide solution, taking up in benzene and drying the solution with potash, the mixture was boiled for 16 hours under reflux, whereupon the reaction mixture was concentrated to dryness and the residue distributed between ether and water. By exhaustive extraction of the basic fractions with dilute acetic acid, precipitation with ammonia, taking up the base in ether and working up the ethereal solution, there was obtained 5.05 grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11- dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous yellowish resin with the boiling point 185°C/0.01mm Hg. The base was crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of the monohydrochloride (from ethanol-ether) 234°-240°C.

Therapeutic Function

Psychostimulant

DibenzepinSupplier

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