Fantofarone
Fantofarone Basic information
- Product Name:
- Fantofarone
- Synonyms:
-
- Fantofarone
- 2-Isopropyl-1-[[4-[3-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]propoxy]phenyl]sulfonyl]indolizine
- SR-33557
- 3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine
- FANTOFARONE;SR-33557;SR33557; 114432-13-2
- CS-2766
- Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]-
- Parasite,Fantofarone,Ca channels,Calcium Channel,inhibit,SR33557,SR-33557,Inhibitor,Ca2+ channels
- CAS:
- 114432-13-2
- MF:
- C31H38N2O5S
- MW:
- 550.71
- Product Categories:
-
- API
- Mol File:
- 114432-13-2.mol
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Fantofarone Chemical Properties
- Melting point:
- 82-83°
- Density
- dz 1.21 g/cm3
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml
- form
- A crystalline solid
- pka
- 8.34 ± 0.05(at 25℃)
- color
- Light yellow to yellow
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Fantofarone Usage And Synthesis
Biological Activity
Fantofarone is a potent antagonist of Calcium Channels.
in vitro
It can be seen that the calcium channel blockers VIZ and Fantofarone (SR) possess a weak intrinsic antimalarial property compared to CQ, and both appear slightly more potent on the CQ-resistant than on the CQ-sensitive parasites.
in vivo
Treatment with isosorbide dinitrate (0.3 mg/kg, i.v.) or Fantofarone (50 mg/kg, i.v.), a reduction is observed in the occurrence and severity of vasospasm, whereas verapamil (0.2 mg/kg, i.v.) is much less effective.
FantofaroneSupplier
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