ethyl2-methylquinoline-6-carboxylate Chemical Properties

Boiling point:

334.4±22.0 °C(Predicted)

Density 

1.148±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

4.95±0.43(Predicted)

form 

Solid

CAS DataBase Reference

855763-77-8

ethyl2-methylquinoline-6-carboxylate Usage And Synthesis

Synthesis

0.005 mmol (1.1 mg) of transition metal catalyst was accurately weighed and placed in a 10 mL Young reaction tube equipped with a magnetic stirrer. Under oxygen atmosphere, 0.04 mmol of co-catalyst I, 0.08 mmol of co-catalyst II, 0.2 mmol of ethyl 4-aminobenzoate, and 1 mL of water were sequentially added to the reaction tube via syringe. The Young reaction tube was fixed on a magnetic stirrer and the reaction was stirred at 150°C for 36 hours. After completion of the reaction, the reaction solution was adjusted to neutral pH and purified by post-processing to afford the target product ethyl 2-methylquinoline-6-carboxylate in 65% yield.

References

[1] Journal of Organic Chemistry, 2017, vol. 82, # 6, p. 3284 - 3290
[2] Patent: CN106543078, 2017, A. Location in patent: Paragraph 0101; 0102

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