(+/-)-THREO-3-METHYLGLUTAMIC ACID Chemical Properties

Boiling point:

329.4±32.0 °C(Predicted)

Density 

1.329±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

H2O: >1.5mg/dL

form 

powder

pka

2.20±0.10(Predicted)

color 

white to off-white

Water Solubility 

H2O: >1.5mg/dL

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

(+/-)-THREO-3-METHYLGLUTAMIC ACID Usage And Synthesis

Uses

A highly selective and potent agonist for kainate receptors.

Biological Activity

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EA at function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

(+/-)-THREO-3-METHYLGLUTAMIC ACID(63088-04-0)Related Product Information

• DL-Glutamic acid
• (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE
• KAINIC ACID
• (2S,3S,4R)-2-CARBOXY-4-ISOPROPYL-3-PYRROLIDINEACETIC ACID
• KAINIC ACID DIMETHYL ESTER HYDROCHLORIDE
• (2S,3R,4S)-CCG
• (2R,3S)-BETA-P-CHLOROPHENYLGLUTAMIC ACID
• DCG IV
• LY 341495
• (+/-)-THREO-3-METHYLGLUTAMIC ACID
• (+/-)-TRANS-1-AMINO-1-CARBOXYCYCLOPENTANE-2-ACETIC ACID
• FMOC-(2S, 3S)-GLU(3-ME)
• (2S,2'R,3'R)-2-(1'-3H,2',3'-DICARBOXYCYCLOPROPYL)GLYCINE
• ABHXD-I HYDROCHLORIDE
• XE-CCG-I
• PCCG-4
• BOC-(2S, 3S)-GLU(3-ME)
• KAINIC ACID, [VINYLIDENE-3H]