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MRS 2578

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MRS 2578 Basic information

Product Name:
MRS 2578
Synonyms:
  • N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA]
  • MRS 2578
  • 1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE
  • N',N'''-butane-1,4-diylbis[1-(3-isothiocyanatophenyl)(thiourea)]
  • Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)-
  • MRS 2578;MRS-2578; MRS2578
  • MRS-2578; MRS2578
  • CS-1109
CAS:
711019-86-2
MF:
C20H20N6S4
MW:
472.67
EINECS:
200-258-5
Product Categories:
  • Inhibitors
Mol File:
711019-86-2.mol
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MRS 2578 Chemical Properties

Melting point:
170 - 173°C
Boiling point:
652.7±65.0 °C(Predicted)
Density 
1.31
storage temp. 
2-8°C
solubility 
DMSO: ~17 mg/mL
form 
solid
pka
11.80±0.70(Predicted)
color 
white
InChIKey
QOHNRGHTJPFMSL-UHFFFAOYSA-N
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-42
Safety Statements 
22-26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3

MSDS

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MRS 2578 Usage And Synthesis

Description

MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6.

Uses

MRS 2578 has been used an antagonist of purinoceptor P2Y6:

  • to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
  • in P. aeruginosa infected mice to test its effect on the inflammatory responses
  • to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

Uses

MRS 2578 is a selective P2Y66?receptor antagonist.

Biological Activity

Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Biochem/physiol Actions

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.

storage

-20°C (desiccate)

References

[1] mamedova l k, joshi b v, gao z g, et al. diisothiocyanate derivatives as potent, insurmountable antagonists of p2y6 nucleotide receptors[j]. biochemical pharmacology, 2004, 67(9): 1763-1770.

MRS 2578Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Chembest Research Laboratories Limited
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China DongFan Chemical Co.,LTD
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QINGDAO CARELONGPHARMATECH CO.,LTD
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0532-0532-88191853 13061484198
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com