Basic information Safety Supplier Related

(UNDECYLTHIO)-ACETIC ACID

Basic information Safety Supplier Related

(UNDECYLTHIO)-ACETIC ACID Basic information

Product Name:
(UNDECYLTHIO)-ACETIC ACID
Synonyms:
  • (UNDECYLTHIO)-ACETIC ACID
  • CZSSKBQAJULWPY-UHFFFAOYSA-N
  • 3-THIATETRADECANOIC ACID
  • 3-TDA
  • Acetic acid, 2-(undecylthio)-
CAS:
116296-31-2
MF:
C13H26O2S
MW:
246.41
Mol File:
116296-31-2.mol
More
Less

(UNDECYLTHIO)-ACETIC ACID Chemical Properties

Melting point:
61-62 °C
Boiling point:
359.0±25.0 °C(Predicted)
Density 
0.978±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form 
crystalline solid
pka
3.85±0.10(Predicted)
More
Less

(UNDECYLTHIO)-ACETIC ACID Usage And Synthesis

Biological Activity

3-thiatetradecanoic acid is an activator of ppar.the peroxisome proliferator-activated receptors (ppars) are transcription factors involved in fatty acid metabolism and energy homeostasis. the ppars also play crucial roles in the control of cellular growth and differentiation.

in vitro

in bt4cn cells, 3-thiatetradecanoic acid could activate all ppar subtypes dose-dependently. in cell culture experiments, the pparγ-selective ligand brl49653 moderately inhibited growth of bt4cn cells, while administration of 3-thiatetradecanoic acid led to a marked growth inhibition. moreover, the administration of the pparγ-selective antagonist gw9662 abolished brl49653-induced growth inhibition, but only marginally reduced the effect of 3-thiatetradecanoic acid [1].

in vivo

administration of 3-thiatetradecanoic acid increased mitochondrial and peroxisomal beta-oxidative capacity and carnitine palmitoyltransferase activity, but reduced free fatty acid and triacylglycerol levels in plasma compared to palmitic acid-treated rats and controls. 3-thiatetradecanoic acid administration was able to affect the fatty acid composition in plasma and liver by increasing the amount of monoenes [2].

References

1. berge k, tronstad kj, flindt en, rasmussen th, madsen l, kristiansen k, berge rk. tetradecylthioacetic acid inhibits growth of rat glioma cells ex vivo and in vivo via ppar-dependent and ppar-independent pathways. carcinogenesis. 2001 nov;22(11):1747-55.2. asiedu, d.k.,froyland, l.,vaagenes, h., et al. long-term effect of tetradecylthioacetic acid: a study on plasma lipid profile and fatty acid composition and oxidation in different rat organs. biochimica et biophysica acta 1300, 86-96 (1996).3. pettersen rj, salem m, skorve j, ulvik rj, berge rk, nordrehaug je. pharmacology and safety of tetradecylthioacetic acid (tta): phase-1 study. j cardiovasc pharmacol. 2008 apr;51(4):410-7.

(UNDECYLTHIO)-ACETIC ACIDSupplier

Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Nantong Feiyu Biological Technology CO.,LTD
Tel
0513-68819626; 15152877458
Email
feiyubio@163.com
More
Less