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Cyromazine

Basic information Description References Safety Supplier Related

Cyromazine Basic information

Product Name:
Cyromazine
Synonyms:
  • Vetrazin【pesticide】
  • Cyromazine, 2-Cyclopropylamino-4,6-diamino-s-triazine
  • N-Cyclopropyl
  • 5-triazine-2,4,6-triamine,n-cyclopropyl-3
  • ai3-52713
  • cga72662
  • neoprex
  • Cyromazine (200 mg)
CAS:
66215-27-8
MF:
C6H10N6
MW:
166.18
EINECS:
266-257-8
Product Categories:
  • Pharmaceutical intermediate
  • Pesticide
  • Acaricides
  • Analytical Standards
  • Analytical/Chromatography
  • Building Blocks
  • Chemical Synthesis
  • Chromatography
  • Environmental Standards
  • Heterocyclic Building Blocks
  • Metabolites
  • Pesticides
  • Pesticides &amp
  • Triazines
  • FINE Chemical & INTERMEDIATES
  • Active Pharmaceutical Ingredients
  • INSECTICIDE
  • fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis, insecticide
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Pesticide intermediates
Mol File:
66215-27-8.mol
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Cyromazine Chemical Properties

Melting point:
223-227 °C (lit.)
Boiling point:
284.39°C (rough estimate)
Density 
1.3196 (rough estimate)
vapor pressure 
4.5 x l0-7 Pa (25 °C)
refractive index 
1.8300 (estimate)
Flash point:
100 °C
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
5.2 (base)
Water Solubility 
13 g l-1 (pH 7.1,25 °C)
form 
neat
color 
White to Off-White
Merck 
14,2775
BRN 
882879
Stability:
Hygroscopic
InChIKey
LVQDKIWDGQRHTE-UHFFFAOYSA-N
CAS DataBase Reference
66215-27-8(CAS DataBase Reference)
NIST Chemistry Reference
Cyromazine(66215-27-8)
EPA Substance Registry System
Cyromazine (66215-27-8)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN3077 (solid)
WGK Germany 
2
RTECS 
XZ1056500
HS Code 
29336990
Hazardous Substances Data
66215-27-8(Hazardous Substances Data)
Toxicity
LC50 (96-hour) for rainbow trout and carp >100 mg/L and bluegill sunfish >90 mg/L (Hartley and Kidd, 1987); acute oral LD50 for rats 3,387 mg/kg (Hartley and Kidd, 1987)

MSDS

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Cyromazine Usage And Synthesis

Description

Cyromazine is a triazine insect growth regulator that can be used as an insecticide and an acarcide. It is a kind of cyclopropylderivative of melamine, and also belongs to the family of aminotriazines which are compound consisting of an amino group attached to a triazine ring. It has specific activity against dipterous larvae, and has been approved by FDA for being applied to livestock. It is not a kind of cholinesterase inhibitor, and taking effect through affecting the nervous system of the immature larval stage of the insects.

References

https://pubchem.ncbi.nlm.nih.gov/compound/cyromazine#section=Top
https://en.wikipedia.org/wiki/Cyromazine
http://pmep.cce.cornell.edu/profiles/insect-mite/cadusafos-cyromazine/cyromazine/insect-prof-cyromazine.html

Chemical Properties

White crystalline powder. The solubility in water is 11,000 mg/L at 20°C and pH 7.5, and the hydrolysis is not obvious at pH 5-9.

Uses

Cypromazine is a high-efficiency and low-toxicity insecticide. It is mainly used to control leafminer pests, has a good control effect on Liriomyza, and can also be used to control flies.

Application

Cyromazine is an insect growth regulator, used to control fly larvae in livestock and poultry manure. It can be fed directly to livestock or applied directly to fly breeding sites. Cyromazine also exhibits systemic activity and is used as a foliar spray to control leaf miners in vegetables, potatoes, etc., and on mushrooms.

Definition

ChEBI: Cyromazine is a triamino-1,3,5-triazine. It has a role as a triazine insecticide and a mouse metabolite.

Preparation

Cyromazine is prepared by the reaction of cyanuric chloride and cyclopropylamine to obtain 2-Cyclopropylamino-4,6-dichloro-triazepine, and then reacts with ammonia to obtain 2-Cyclopropylamino-4-chloro-6-aminostriazepine, and then reacting with ammonia to produce.

General Description

N-Cyclopropyl-2,4,6-triamino-1,3,5-triazine, also known as cyromazine, is an insect growth regulator(IGR) that is commonly used as an insecticide. It undergoes metabolism in plants and animals to form melamine. Surface-enhanced Raman scattering (SERS) spectroscopic study indicates that it interacts with the surface of silver colloid through the lone pair on nitrogen.

Agricultural Uses

Insecticide (insect growth regulator): As an insect growth regulator, cyromazine is fed to caged poultry and is passed through the chicken, leaving a residue in the manure. The chemical controls the growth of the fly larvae developing in the manure. Used as a foliar spray to control leaf miners in vegetables, mushrooms, potatoes and ornamentals and to control flies on animals.

Trade name

ARMOR®; CITATION; CGA-72662®; LARVADEX®; PATRON®; TRIGARD®; VETRAZIN®

Environmental Fate

Chemical/Physical. Cyromazine will react with mineral acids (e.g., hydrochloric acid, sulfuric acid) forming water-soluble salts

Metabolic pathway

Information presented in this summary is abstracted from the data evaluation published by the Pesticide Safety Directorate (PSD, 1993). The major degradation pathway of cyromazine involves the N-dealkylation of the cyclopropyl moiety to yield melamine. Both cyromazine and melamine are quite stable to biotransformation. Deamination and the formation of N-methylcyromazine were observed as minor pathways.

Degradation

Cyromazine (1) is stable to hydrolysis at pH 5, 7 and 9 and 70 °C for up to 28 days. No degradation of cyromazine was observed when irradiated under mercury vapour lamp (>290 nm) at 25 °C for up to 168 hours.

Cyromazine Preparation Products And Raw materials

Raw materials

CyromazineSupplier

Hebei Yanxi Chemical Co. Ltd Gold
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15633831222
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2716427601@qq.com
Hefei TNJ Chemical Industry Co.,Ltd. Gold
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551-65418679 15837135945
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info@tnjchem.com
Jiangxi ruiya pharmaceutical co., LTD Gold
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18616817490
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rainbowyu@ruiyapharma.com
Jinan Wald Chemical Co., Ltd. Gold
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0531-88773586 13210588999
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304264064@qq.com
Hubei Shuangyan Chemical Co., Ltd Gold
Tel
17671768525
Email
76824675@qq.com