Basic information Safety Supplier Related

ACIFRAN

Basic information Safety Supplier Related

ACIFRAN Basic information

Product Name:
ACIFRAN
Synonyms:
  • ay25712
  • ACIFRAN
  • 4,5-DIHYDRO-5-METHYL-4-OXO-5-PHENYL-2-FURANCARBOXYLIC ACID
  • (R,S)-4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
  • 4,5-Dihydro-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
  • Acifranum
  • 4,5-dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylicaci
  • 5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid
CAS:
72420-38-3
MF:
C12H10O4
MW:
218.21
Product Categories:
  • Miscellaneous Compounds
Mol File:
72420-38-3.mol
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ACIFRAN Chemical Properties

Melting point:
176°
Boiling point:
378.4±42.0 °C(Predicted)
Density 
1.343±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
Soluble in DMSO > 10 mM
form 
Powder
pka
2.25±0.40(Predicted)
color 
Off-white to light yellow
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Safety Information

Toxicity
LD50 orally in rats: 3 g/kg (Jirkovsky, 1982)
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ACIFRAN Usage And Synthesis

Uses

Antihyperlipopro-teinemic.

Uses

Acifran is a nicotinic acid receptor agonist.

brand name

Reductol (Wyeth-Ayerst).

Biological Activity

Hypolipidaemic agent; more potent than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC 50 values are 1.3? and 4.2 μ M respectively). In vivo, reduces serum triglycerides and circulating LDL-cholesterol without affecting liver weight or liver enzymes.

storage

Store at +4°C

ACIFRANSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
EMMX Biotechnology LLC
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888-539-0666
Email
info@emmx.com
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Email
sales@rechemscience.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
BOC Sciences
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Email
info@bocsci.com