Rapamycin, 32-O-demethyl- Chemical Properties

Boiling point:

974.8±75.0 °C(Predicted)

Density 

1.20±0.1 g/cm3(Predicted)

pka

10.40±0.70(Predicted)

Rapamycin, 32-O-demethyl- Usage And Synthesis

Uses

27-O-Demethylrapamycin, a Rapamycin (HY-10219) derivative, is an antifungal agent. 27-O-Demethylrapamycin inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum[1].

References

[1] Wong GK, et al. Antifungal activities of rapamycin and its derivatives, prolylrapamycin, 32-desmethylrapamycin, and 32-desmethoxyrapamycin. J Antibiot (Tokyo). 1998 May;51(5):487-91. DOI:10.7164/antibiotics.51.487

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